How Ivermectin Mixes with Water and PEG

Ivermectin is a drug that doesn't dissolve well in water. This can make it less effective because it doesn't absorb well in the body. Scientists have some data on how well it dissolves in single solvents and a few mixtures, but not enough in more complex combinations. Researchers decided to study how well ivermectin dissolves in mixtures of polyethylene glycol (PEG) 200 and water, as well as PEG 400 and water. They looked at temperatures ranging from 293. 2 to 313. 2 K. They used different models to analyze the data, like van't Hoff, Jouyban-Acree, and mixture response surface methods. They checked how well these models worked by seeing how close they were to the actual data. The team also calculated thermodynamic parameters like Gibbs energy, enthalpy, and entropy. These parameters help understand the energy changes involved in the dissolution process. The goal was to find out how ivermectin behaves in these mixtures and at different temperatures. This study is important because it can help improve the formulation of ivermectin. Better solubility means better absorption and effectiveness. The researchers hope their findings can lead to more effective ways to use this drug.