Saffron: A Surprising Ally Against Brain Injuries

TBI can result from vehicle collisions, sports accidents or combat and this injury can cause death. TBI can also affect the bank accounts of those affected and the government. It can be broken down into two major phases: 1. The primary phase: things that occur immediately after the injury or concussion 2. The secondary phase: processes in the body that occur over time TBI can mess with important pathways in the body such as inflammation, cell death, and antioxidant responses. Many treatments and strategies have been tried to help fight these difficulties and improve the patient's quality of life. Nevertheless, the hunt is ongoing for more efficient and safer treatments. Now, let's talk about saffron. Saffron is a spice that has been used for centuries in cooking and medicine. Recently, it's gotten attention for its potential benefits in treating TBI. Researchers looked at studies from 1992 to 2025 searching for the terms TBI and Saffron and bioactive componds in databases such as Scopus and PubMed. They found about 3, 000 studies and narrowed them down to 10 experiments that showed promise. These studies showed that saffron can help regulate important pathways and cytokines such as NF-kB, inflammation, and oxidative stress. The results suggest that saffron could be a powerful tool in treating the TBI,however, more research is needed to figure out if it stays safe and effective in treating TBI. Clinical trials are needed to figure out exactly how it works and the kind of impact it can have on people with TBI. It is also important to find out how much of the compound should be used and any adverse effects. The studies should also look at the impact on both acute and chronic TBI, as well as rehabilitation and long-term neuroprotection.