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Scientists have created a new imaging method that might solve one of the biggest headaches in treating brain tumors that have spread from skin cancer. When melanoma spreads to the brain, special drugs called immune checkpoint inhibitors can help some patients. But doctors struggle to know early on whether these drugs are actually doing their job. The standard tool, MRI, shows pictures of the brain but cannot reveal what is happening inside the tumor at a molecular level. Plus, tumors can look worse on scans temporarily even when treatment is working, a phenomenon called pseudoprogression that confuses everyone. The new technique uses antibody-based PET scanning, a highly sensitive molecular imaging method. Researchers focused on a protein called ICOS that appears on T cells when they gear

Heart failure with reduced ejection fraction (HFrEF) is a serious condition that affects many people worldwide. It often leads to high death rates, frequent hospital visits, and changes in the heart’s structure. Doctors rely on ACE inhibitors as a core part of treatment. One such drug, perindopril, is long‑acting and generally safe, but there isn’t a lot of clear data on how well it works compared to newer options like sacubitril/valsartan. Researchers at the Tbilisi Heart Center looked at 214 patients with HFrEF between 2018 and 2025. All participants received guideline‑directed medical therapy (GDMT). They were split into two groups: 118 people took perindopril, while 96 received sacubitril/valsartan. The team measured heart function, echo data, and blood markers at the start, again aft

Researchers in Kazakhstan tested a new survey for jaw cancer patients. They translated an existing questionnaire into Russian and Kazakh. The process used forward translation and expert review. They also did a pilot test with real patients. One hundred four people took part after surgery for tumors in the upper jaw and palate. The survey proved reliable. Internal consistency scored 0. 878 which is high. Test-retest results showed strong agreement across all sections. Scores ranged from 0. 904 to 0. 983. All were statistically significant. Patients struggled most with saliva and taste. Those areas got the lowest marks around 41 and 43 out of 100. People with advanced cancer or combined treatments fared worse physically and emotionally. Early stage patients doing single therapy reported bette

Researchers studying university students in China noticed something interesting. Instead of grinding nonstop or burning out, many young people seem to be deliberately pulling back. They care less about winning big social races, yet they stay sharp and motivated in their own small corners of life. The team labeled this pattern "Ego-Tucking," like folding a piece of fabric neatly to keep it safe. The study pulled in data from 678 students. What stood out was a split behavior. Students stepped away from crowded competitions where one person is judged as better than everyone else. At the same time, they poured energy into personal hobbies, small projects, and self chosen goals. The researchers called this split "Functional Bifurcation," a fancy way of saying people divide their effort on purp

When people don’t have steady access to healthy food, staying physically active becomes a real challenge. Research has long shown that food insecurity is tied to lower activity levels and a higher risk of heart and metabolic problems. A growing number of programs, often called "Food Is Medicine" (FIM) initiatives, are designed to help by giving people better food options. But what about movement and exercise? A recent study dug into how adults dealing with food insecurity think about physical activity while taking part in one of these programs. The research was part of a larger clinical trial called Healthy Food First, which focused on adults with high blood pressure who also struggled to get enough food. Participants were split into groups. Some received fresh produce delivered to their

Politicians sometimes try to win support by telling certain groups they have been treated unfairly. This approach is called grievance politics. When the group being appealed to is men, critics call it male grievance politics. Two Republican lawmakers have found themselves at the center of debates about this strategy. Austin McCollum is an Arkansas politician who has made statements connecting male voters to economic anxieties. His messaging suggests men have been left behind as other groups gained attention. Max Miller is a congressman who has pushed similar themes, arguing that policies have overlooked men in areas like education and employment. Both politicians use language that frames men as victims of a system that favors others. Political experts point out several problems with this

Think about getting one bill for everything instead of dozens of separate charges. That is exactly what a new healthcare payment model tries to do. The United States is shifting toward bundled payments as a way to handle medical costs. Instead of paying for each test, each doctor visit, and each procedure separately, the whole episode of care gets a single price tag. Old school billing works like a buffet of separate charges. Every blood test, every X-ray, every pill shows up as its own bill. This can make costs confusing and hard to predict. It also means nobody really watches the total price. With bundled payments, one fixed amount covers everything from diagnosis through recovery. This puts all the pieces together into one neat package. The new system follows eight clear steps. First,

Princeton’s football team finished last year with a 6‑4 record and a 5‑1 mark in conference play, earning a playoff spot for the fifth year in a row. After four straight seasons with double‑digit wins, the Tigers are now aiming for something bigger. Coach Ryan Pearson, who is starting his tenth year, said the previous season fell short of the program’s high standards. He added that the shortfall made the squad hungrier and gave some players a chip on their shoulder. Pearson wants athletes who are ready to prove themselves on the field. With the season starting early, the staff had to get new starters ready quickly. The backfield could see as many as nine different ball carriers trying to replace the graduated 2025 BCR Player of the Year, Casey Etheridge. Senior Ayden Agushi, who rushed fo

The two ETFs we are looking at are very different in price and size. One fund charges a higher fee, while the other is cheap to own. The bigger fund holds a huge amount of money, the smaller one holds far less. When we look at how much money each fund has made lately, the AI-focused fund shows a big jump in value, while the broader tech fund gives a smaller gain. The AI fund also pays out more cash to shareholders each year. Its yearly payout is noticeably higher than that of the broader fund. The AI fund's price moves more sharply than the market, which means it can swing up and down faster. Its biggest loss over three years was larger than the loss of the broader fund. The AI fund holds a tight list of companies, mostly in tech and a bit in communication services. The broader fund spre

STING is a protein that acts as a danger sensor inside cells. When it detects abnormal signals, it triggers a chain of events that lead to the production of interferons. These interferons then call immune cells to the site of a tumor. In many cancers, this alarm system is turned off, which lets the tumor grow without being attacked. Scientists have found that a small molecule called lactate, which is made by rapidly dividing cancer cells, can attach to STING at a particular spot known as lysine 370. This attachment is a form of lactylation. The lactylation prevents STING from linking to its partner protein TBK1, a step needed to start the signaling process. The modification also changes the way STING is tagged with ubiquitin chains. It increases the number of K48 chains, which mark the p

A heated debate has erupted over trans women playing in top‑level women’s sports. It started after a guard from the Indiana Fever told ESPN she wants to keep young girls safe from competing against biological men. The comment sparked a wave of political talk, protests and TV chatter that seems more about division than support. Soon after, two former NBA players said they would enter the 2027 WNBA draft, claiming they now identify as women. The WNBA task force met, called the move a bad‑faith attempt to mock or sideline people, and issued a clear statement against such tactics. Despite the noise, the actual number of trans athletes in college sports is tiny. In 2024 the NCAA president said fewer than ten out of over half a million student‑athletes are trans, which is less than two thousand

Many people who hurt their ankle once end up with lasting wobbliness. About half of those with a previous ankle sprain develop chronic ankle instability. This ongoing looseness can raise the chance of getting ankle arthritis later. While most ankle sprains affect the outer ligaments, recent hints suggest the inner ligament, called the deltoid complex, might be injured more often than we think. Yet the way this ligament is built and how it works is described in many different ways across studies. To clear up the confusion, researchers plan a systematic review. They will search large libraries such as Scopus, MEDLINE, Embase, CINAHL and SPORTDiscus. The search will use terms like deltoid ligament, anatomy and biomechanics. Only papers that dissect or image the ligament in healthy adult huma

A team of researchers looked back at records from 281 adults who attended a wellness clinic in Jeddah, Saudi Arabia. The facility offered two separate programs: one focused on metabolic health and another aimed at helping participants stop smoking. Over a six‑month window, the investigators tracked body mass index, systolic blood pressure, HbA1c, and total cholesterol at the start, middle, and end of the study. They used statistical models that compare changes within the same individuals over time to identify meaningful shifts. After six months, the average BMI had dropped by roughly one kilogram per square meter, and total cholesterol fell by about 0. 25 millimoles per litre. Among the smokers who entered the study, close to a quarter—24. 1 percent—had quit by the final visit. Blood pressu

Russia still plays a part in Middle East politics, but its influence is now described as secondary. The country’s presence has become a background factor in regional power plays. Analysts say Moscow’s role is no longer the main driver it once was. In Syria, Moscow once ran about a hundred military outposts. This buildup followed the 2015 intervention aimed at backing President Bashar al‑Assad. The effort was coordinated with Iran and a network of local allies. A new agreement was announced by the Syrian foreign ministry on Sunday. Under the deal, Russia’s two bases outside the former Soviet sphere become joint training and capacity‑building hubs. The arrangement is meant to keep mutual interests intact. Exact details remain scarce. Russian troops are expected to stay at both facilities

The Alien saga is packed with terrifying extraterrestrials that hunt humans across the stars. Fans have tried to rank the ten most powerful creatures, and the list reveals some shocking facts. Below are the top six, each with its own unique threat. Number ten is the Offspring, a strange hybrid born from a human mother who was captured by a Xenomorph. After injecting a mysterious Z-01 serum, she gave birth to a massive creature with razor claws, a proboscis mouth, and a gangly frame. It’s huge but clumsy, making it easy to outrun. Number nine is the Facehugger. It moves fast, latches onto faces, and its tail squeezes the throat if you try to pull it off. Its blood is acidic, and a single touch can be fatal. Number eight is the Newborn, a human‑alien mix that looks pale, has a human skull,

In a coastal region of Indonesia, scientists enrolled 293 expectant mothers while they were in the middle of their pregnancy. The participants lived across three different coastal neighborhoods. The team gathered information about the mothers’ emotional state using a validated stress questionnaire. At the same time, each fetus’s size was measured with an ultrasound scan. The mothers’ ages ranged around 27 years, with many in their early twenties and a few in their early thirties. Most of the husbands were employed in informal work, and a large portion of the households earned low incomes. Researchers used the DASS‑42 instrument to capture levels of distress. Fetal growth was monitored by estimating weight from ultrasound pictures. The results highlighted a strong connection. Mothers who

The enset plant thrives across southern and southwestern Ethiopia, feeding more than twenty million people. It belongs to the banana family and yields three staple foods: kocho, amicho, and bulla. Among these, bulla holds a reputation as the finest product, yet it receives far less scientific attention than its relatives. Researchers have gathered a wealth of information about enset foods, but many details about bulla remain unclear. A large collection of studies was sifted through using a rigorous screening method. Over three hundred records were narrowed down by removing duplicates, unreliable sources, and papers lacking clear justification. About eighty articles survived the final review. The analysis revealed that bulla is made by mechanically extracting juice and letting it settle, w

Most doctors are trained to hunt for a single broken gene when something goes wrong in the body. But a new idea says that many tough disorders come from something messier: a whole team of tiny genetic helpers falling out of sync at once. Researchers are calling this kind of breakdown a primary epigenetic disease, or PED for short. So what actually is a PED? Think of it like a busy orchestra where every musician has a small mistake in their sheet music. No one player is totally wrong, but together the sound falls apart. Scientists looked at big pools of studies from 2021 to 2026 and found that many patients carry lots of small gene variants in places like MTHFR, DNMTs, and HDACs. These genes help control how DNA is switched on or off. When too many of them wobble at once, the body struggle

The research looked at how smart library systems powered by artificial intelligence influence the way students make academic choices. It introduced a new idea called algorithmic academic framing, which describes how these AI tools present information in a way that guides decisions. The study used two major psychological theories to explain why this framing matters. It suggests that the way AI structures content can either help or hinder a learner’s ability to pick the right path. Researchers gathered data from 328 university students across three schools in China. They collected responses over several time points to capture changes in behavior. The participants filled out surveys about their confidence in using AI, how mentally overloaded they felt, and the quality of the decisions they m

Scientists in Fairbanks uncovered a remarkable survival strategy from Alaska's wood frogs. These small amphibians can plunge their bodies well below freezing without dying. During winter, their internal temperature drops dramatically while they remain alive. The secret involves a natural chemical defense system. When temperatures fall low enough, the frogs convert stored energy into glucose. This sugary substance flows through their cells and prevents ice crystals from destroying tissue. Without this adaptation, freezing would cause fatal damage similar to what humans experience in extreme cold. Dr. Barnes intends to capture several large frogs and equip them with tiny tracking devices. He will monitor their movements through the winter months and record temperature data from embedded se