Ischemic stroke is a growing concern worldwide, especially among young and middle-aged adults. Between 1990 and 2021, the global disease burden of ischemic stroke increased, with a significant number of cases and deaths reported. In 2021, there were 16,301,644 prevalent ischemic stroke cases and 1,324,743 incident cases worldwide. The rates of ischemic stroke were higher among males, with 35. 14 per 100,000 population, compared to females with 24. 51 per 100,000 population. The study found that the prevalence of ischemic stroke was higher among females, while incidence, mortality, and disability-adjusted life years were higher among males. The burden of ischemic stroke was concentrated in high-middle socio-demographic index regions, Eastern Europe, Central Asia, and parts of North Africa and