Didemnins, a family of molecules found in marine creatures, are known for their powerful cancer-fighting abilities. One of the most studied members, Didemnin B, has shown great promise in stopping tumors from growing. But using it in patients has been tough due to problems like poor absorption and h
Imagine you're running a clinical trial to test a new treatment in critical care. You're tracking how patients do after the treatment, but what if some patients don't make it long enough to see the full results? That's what we're calling "truncation due to death. " The big question is, how do we han
Imagine if doctors could see beyond the symptoms and truly understand what makes you, you. That's the idea behind whole person health assessments. Instead of just focusing on diseases, these assessments look at the whole picture: your body and mind, your relationships, your living environment, your
For a long time, doctors have relied on finding physical damage to understand and treat pain. But chronic pain is different. It often doesn't show up on scans or tests, and it's a personal experience that no one else can feel. This makes it tough for doctors to talk about with their patients. This p
Every year, over 60 million people face traumatic brain injuries (TBIs), leading to significant health issues and even death. Managing these injuries is tough, with a heavy toll on individuals and society. For the past couple of decades, there's been a rise in clinical trials focusing on neurocriti
Imagine you're battling advanced biliary tract cancer (ABTC), and your doctors suggest a mix of drugs: nivolumab, modified gemcitabine, and S-1. This combo showed promise in a past trial, but PD-L1 levels didn't tell us much about how well it would work. So, scientists looked at another marker, LAG-
Meet rimegepant, a new drug that blocks certain signals in your brain to stop migraines. It's been tested in labs and found to work, but what about in the real world? That's what the GAINER study set out to find. This study, happening in multiple places, looked at how well rimegepant works and how t
Immune-checkpoint inhibitors (ICIs) have emerged as a powerful tool in the fight against advanced squamous cell lung cancer (LUSC). These drugs offer a glimmer of hope for patients who haven't found success with other treatments. But it's not a one-size-fits-all solution—some patients don't respond
Ever wondered how doctors solve medical mysteries in forensic cases? This exploration dived into the world of teaching clinical reasoning in forensic medicine. The goal? To check out what's already been written about it. Forensic doctors need sharp thinking skills to figure out the truth behind cri
Did you know that Plummer-Vinson Syndrome (PVS) can put people at risk for head and neck cancer? This isn't just a random fact—researchers have taken a close look at how these health issues connect. PVS, which affects the esophagus and throat, can create conditions that make it easier for cancer to
