Alzheimer's disease is a complex puzzle. One key piece? Tiny powerhouses in our cells called mitochondria. These little guys usually help cells stay alive and healthy. But in Alzheimer's, they're not working right. Why? Because calcium, a crucial messenger in cells, is out of balance. Calcium is li
Parkinson's disease (PD) and multiple system atrophy (MSA) are both neurodegenerative disorders that affect the brain and the body's nervous system. The skin, surprisingly, might hold clues about these conditions. Scientists have found evidence that these diseases can also impact the peripheral nerv
Diabetes can cause serious brain problems. These issues can make treating diabetes even harder. So, finding natural compounds that protect the brain could be a game-changer. One such compound is β-sitosterol. It's found in various plants and has shown promise in fighting diabetes-related brain damag
The human brain is a complex organ, and sometimes it goes wrong. One big problem is amyloid aggregation. This is when proteins clump together and become toxic. These toxic clumps can speed up brain diseases. So, scientists are always looking for new ways to stop these clumps from forming. Two speci
PLAN, or PLA2G6-associated neurodegeneration, is a tricky condition. It is a type of neurodegeneration with brain iron accumulation. It can start at any age, from infancy to adulthood. Symptoms can vary widely, affecting movement, thinking, eyesight, and even basic bodily functions. This makes it a
Imagine if there were drugs that could tackle brain diseases in a whole new way. Brain diseases like Parkinson's and Alzheimer's are tough. They cause brain cells to die. Most drugs out there just treat the symptoms. They don't fix the root cause. This is where hybrid drugs come in. These are specia
Imagine you're trying to solve a puzzle, but you're missing some pieces. That's kind of what it's like when scientists study progressive multiple sclerosis (MS). MS is a disease that messes with your brain and spinal cord, causing damage to the protective layer around nerve cells. It affects million
Did you know that tiny worms like C. elegans can teach us a lot about human diseases? Scientists have been studying a protein called sigma-1 receptor (σ1R) to understand how it interacts with different drugs, or ligands, and affects lifespans. They found that some drugs stick better to the σ1R prote
Caspase-6, a protein linked to brain cell death and neurodegeneration, has been on scientists’ radar for a while. This protein is especially active during inflammation and may play a role in the early stages of Alzheimer's disease. Researchers have now combined two drug-designing approaches to find
