After a skin cut, the body sometimes goes overboard, creating a raised, thick scar that never fully settles. These scars stay inflamed and packed with extra collagen, which makes them look unsightly. Today’s topical creams often fail to work well, can irritate the skin, and barely get through the surface.
A team of scientists created a pH‑responsive gel made from borax‑linked dextran that can carry two medicines: triamcinolone acetonide and 5‑fluorouracil. First they wrapped each drug in a tiny sugar‑based cage using (2‑hydroxypropyl)‑β‑cyclodextrin, which boosts how easily the drugs dissolve and stay stable. The drug‑filled cages were then mixed into the borax‑dextran gel, forming a composite that releases the medicines only when the pH is low, as found in scar tissue.
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