Musculoskeletal disorders are a leading cause of chronic pain and disability worldwide. These conditions are often treated with ineffective or palliative medications. However, research suggests that chronic inflammation in MSDs is not just caused by excessive pro-inflammatory signaling, but also by impaired anti-inflammatory and pro-resolving mechanisms.
Chronic inflammation is a complex issue, and cytokines play a crucial role in it. Cytokines are proteins that help fight off infections and heal damaged tissues. In MSDs, certain cytokines can promote inflammation and tissue damage, while others can help reduce inflammation and promote healing.
For example, cytokines like IL-34, IL-36, and IL-39 can promote inflammation and tissue damage, while cytokines like IL-35, IL-37, and IL-41 can